I thought this was an interesting take on post-00 U2 because he it isn't the usual binary juxtaposition - they were great and inventive (90s) and bland and commercial (00s).
He states that he misses the experimentation in their sound from the 90s but notes the pressure of the music industry on the way music has been recorded and released since about 2000. In the 90s there was a much more vibrant alternative music scene - a thread on here has been lauding the records released in the early 90s as testament to this - and rather than just saying "I can't listen to anything after Pop" he points out that after the dust has settled and he revisits the 21st century records, he finds there is more to reward him than he initially first thought, particularly ATYCLB, and the vinyl issue of NLOTH. I agree with him that their songwriting has become less original, however, and noted this in particular on SOI.
He doesn't consider their age or increasingly affluent lifestyles (well, let's be honest, they've been very affluent for over 30 years so perhaps that isn't so important?) and how that might dull, or enhance, their sense of creativity. Bono has been increasingly politically active for about 20 yeas and perhaps that has been a source of artistic inspiration to the lyrics at least - e.g helped him consider how people think about others groups/communities/ individuals.